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# Gallop Lab

Discovering how proteins and lipids control the actin cytoskeleton

## Sitemaps

- [XML Sitemap](https://gallop.group/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [Blog](https://gallop.group/blog/)
- [Fundraising event: 1st annual WALK AND ROLL for Lowe Syndrome awareness](https://gallop.group/fundraising-event-1st-annual-walk-and-roll-for-lowe-syndrome-awareness/) - The sun shone brightly on a crisp Cambridge day for the special Walk and Roll edition of the Gurdon Institute’s Wellbeing Walk! Twelve members of our Professional, Technical, and Research staff and students, came together for a one-mile stroll through some of Cambridge’s most iconic sights.We began at the Fitzwilliam Museum, founded in 1816, before
- [Building links in the Lowe Syndrome research community](https://gallop.group/building-links-in-the-lowe-syndrome-community/) - Tom has arrived in India for his visit to Raghu Padinjat’s lab at the National Centre for Biological Sciences, Bangalore. Congratulations to Yojet Sharma and the Padinjat lab on their new publication in EMBO Molecular Medicine.
- [Paul James, patient adviser, publishes "Do You See Me – Inclusion is possible for everyone"](https://gallop.group/paul-james-patient-adivser-publishes-do-you-see-me-inclusion-is-possible-for-everyone/) - Paul James, patient adviser, has published an article in Inclusion North about his recent experience of speed dating and being the only attendee with a learning disability. He recounts how he enjoyed the events and how it helped with his confidence. He concludes that it is important for venues to talk to people with any
- [Membrane composition and curvature in SNX9-mediated actin polymerization](https://gallop.group/membrane-composition-and-curvature-in-snx9-mediated-actin-polymerization/) - Vaishnav et al combined cell free reconstitutions, biophysical tools and super-resolution microscopy to explore the activities of membrane adaptor SNX9, finding that it binds to combinations of phosphatidylinositol lipids and can support diverse actin filament architectures. READ PUBLICATION
- [Lowe Syndrome and Me: a co-creation video series connecting patients, caregivers and researchers](https://gallop.group/lowe-syndrome-and-me-a-co-creation-video-series-connecting-patients-caregivers-and-researchers/) - A publication from Teresa Haugen, Lowe Syndrome Association Board Member, Jenny Gallop and Hélène Doerflinger, Public Engagement Manager at the Gurdon Institute about a collaborative patient and public involvement project, Lowe Syndrome and Me. Researchers from the Gallop Lab and caregivers from the Lowe Syndrome Association (United States) collaborated to produce a series of videos
- [Talk: The self-reinforcing role of phosphoinositide signalling in filopodial extension](https://gallop.group/talk-the-self-reinforcing-role-of-phosphoinositide-signalling-in-filopodial-extension/) - In May and June, Thomas Blake presented work on the topic of “The self-reinforcing role of phosphoinositide signalling in filopodial extension” at a number of meetings: Conferences Jacques-Monod meeting “Molecular basis for membrane remodelling and organisation” in Roscoff, France, a University of Cambridge School of Biological Sciences symposium “Microscopy across Scales” and at the UK
- [Gallop Lab and Gurdon Institute host the Dent Disease Foundation's UK patient meeting](https://gallop.group/gallop-lab-and-gurdon-institute-host-the-dent-disease-foundations-uk-patient-meeting/) - Patients from across the UK gathered together to connect with each other and listen to a presentation from Jill Goodrich, Co-Executive Director of the Dent Disease Foundation, and to hear about Jenny Gallop’s research.
- [Filopodial protrusion driven by density-dependent Ena–TOCA-1 interactions](https://gallop.group/the-role-of-ena-toca-1-interactions-in-filopodial-formation/) - A study by Blake et al reveals that the formation and extension of filopodia depend on the interaction between two proteins: Ena/VASP and TOCA-1.These interactions are density-dependent; In vitro, increasing densities of TOCA-1 enhances Ena/VASP protein binding. In vivo, the authors found that filopodia protrusion correlates with accumulation of TOCA-1, coincident with recruitment of Ena. View publication
- [The open to closed D-loop conformational switch determines length in filopodia-like actin bundles](https://gallop.group/the-open-to-closed-d-loop-conformational-switch-determines-length-in-filopodia-like-actin-bundles/) - Gadsby et al identified a set of monoclonal antibodies that selectively bind the open DNase 1-binding loop (D-loop) of actin filaments, uncovering a molecular switch that governs length regulation. View publication
- [Talk: Alpelisib & alterations in the actin cytoskeleton](https://gallop.group/talk-alpelisib-alterations-in-the-actin-cytoskeleton/) - Jenny gave a talk at the 2024 International Lowe Syndrome Symposium at Purdue University. The talk described how changes in actin and lipid balance that arise from loss of OCRL1 can be partially compensated by targeting another enzyme in phosphoinositide lipid metabolism, phosphoinositide 3-kinase.
- [Talk: Membrane adaptor protein TOCA-1 interacts with Ena to drive filopodial protrusion](https://gallop.group/tom-talk/) - Tom gave a talk for the centre for mechanochemical cell biology’s Motors in Quarantine webinar series about how we used frog retinal ganglion cells as a model to study how filopodia, dynamic cytoskeletal protrusions from the cell surface, are regulated during axon outgrowth. Using high speed imaging with quantitative dynamics analysis, we showed how membrane
- [Talk: Identification of the molecular determinants of filopodial dynamics using antibody technology](https://gallop.group/talk-title-jonathan/) - Jonathan gave a talk at the London Cell Motility Club 7th Symposium describing how a group of antibodies, identified from a phage display screen, affect actin conformation and the disassembly of FLS (filopodia like structures) grown on supported lipid bilayers.
- [Animal encounters: The past, present and future of biochemistry](https://gallop.group/animal-encounters-the-past-present-and-future-of-biochemistry/) - Jenny gave a talk alongside Dr Eyal Maori and Professor Eric Miska and artist Lily Hunter Green at a session at the Cambridge Festival which aimed to inform young adults about what humans can learn from frogs, bees and worms.
- [Egging on vital research](https://gallop.group/egging-on-vital-research/) - Jenny’s research using Xenopus laevis has been highlighted in a recent article by the University of Cambridge. Read more
- [The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease](https://gallop.group/the-phosphoinositide-3-kinase-inhibitor-alpelisib-restores-actin-organization-and-improves-proximal-tubule-dysfunction-in-vitro-and-in-a-mouse-model-of-lowe-syndrome-and-dent-disease/) - Berquez et al report a proof of concept for the repurposing of a class IA p110α PI3K inhibitor alpelisib for Lowe Syndrome/Dent disease 2, which are caused by loss-of-function mutations in the OCRL gene, which encodes the phosphatidylinositol [PI] 4,5-bisphosphate [PI(4,5)P2] 5-phosphatase OCRL, and results in defective endocytosis and proximal tubule dysfunction. Read publication
- [Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation](https://gallop.group/stochastic-combinations-of-actin-regulatory-proteins-are-sufficient-to-drive-filopodia-formation/) - Dobramysl et al analyzed the localization of actin regulators within filopodia in Drosophila embryos and in an in vitro system of filopodia-like structures (FLSs), finding that the composition of the regulatory protein complex where actin is incorporated (the filopodial tip complex) is heterogeneous both in vivo and in vitro. Different pairs of proteins correlate with
- [Filopodia In Vitro and In Vivo](https://gallop.group/filopodia-in-vitro-and-in-vivo/) - A review by Blake and Gallop that explores recent advances in conceptual models of how filopodia form, the molecules involved in this process, and our latest understanding of filopodia in vitro and in vivo. Read review

## Pages

- [Home](https://gallop.group/) - Discovering how proteins and lipids control the actin cytoskeleton, from biophysical mechanism to molecular behaviour in organisms Meet the Lab Lab dinner with Gallop Lab alumni Astrid Walrant who is now a Maîtresse de Conférences at Sorbonne Universite in Paris and was visiting Cambridge to give a seminar at the Biochemistry Department. People Research Research
- [Publications](https://gallop.group/publications/) - Publications Publications Publications Lowe Syndrome and Me: a co-creation video series connecting patients, caregivers and researchers Read More → Publications Membrane composition and curvature in SNX9-mediated actin polymerization Read More → Publications The open to closed D-loop conformational switch determines length in filopodia-like actin bundles Read More → 1 2 3 Next » Quick Links
- [Research](https://gallop.group/research/) - Research Exploring filopodia formation and actin assembly: innovative approaches to cellular dynamics and therapeutic interventions We are interested in how filopodia form and in understanding how to intervene in actin assembly therapeutically. Our current questions include:What happens when filopodia initiate and extend?What determines the length and lifetime of filopodia, and related in vitro filopodia-like structures?How
- [Contact](https://gallop.group/contact/) - Opportunities If you are interested in joining us please send your CV and a covering email describing your interests and motivations to Jenny. We are happy to work with postdoc applicants to apply for fellowships and we can sometimes offer short term salary support. PhD students usually join the lab via studentships from external funders
- [people](https://gallop.group/people/) - People Jenny Gallop 2020 – present: Associate Professor, Department of Biochemistry, University of Cambridge2011 – present: Group Leader, Gurdon Institute2011 – 2020: Affiliated member, Department of Biochemistry2006 – 2011: Postdoc and EMBO fellow in laboratory of Marc Kirschner, Harvard Medical School, Boston, USA2001 – 2006: PhD and short postdoc in Harvey McMahon’s lab, MRC Laboratory

## Categories

- [News](https://gallop.group/category/news/)
- [Publications](https://gallop.group/category/publications/)
- [Research](https://gallop.group/category/research/)